DM tipe 1 adalah kelainan sistemik

DM tipe 1 adalah kelainan sistemik akibat gangguan metabolisme glukosa yang ditandai dengan hiperglikemia kronis. Keadaan tersebut disebabkan kerusakan sel beta pankreas baik oleh proses autoimun maupun idiopatik sehingga produksi insulin berkurang bahkan terhenti. Faktor keturunan (genetik) diduga sebagai penyebab utama meskipun kebanyakan anak ternyata tidak punya riwayat DM pada keluarga. Organ tubuh yang diserang adalah sel beta pankreas yang kerja utamanya memproduksi insulin. Walhasil, pankreas tak mampu lagi memenuhi kebutuhan insulin tubuh bahkan produksinya dapat terhenti sama sekali. Sebagai perbandingan, normalnya pankreas memproduksi 31 unit insulin perhari, sedangkan pasien DM tipe 1 memproduksi hanya 0-4 unit perhari; sehingga membutuhkan tambahan insulin dari luar. Faktor genetik dan lingkungan akan menentukan kapan dan seberapa parah DM yang mengenai anak.

Results (English) 1:

Type 1 DM is a systemic disorder resulting from impaired glucose metabolism characterized by chronic hyperglycemia. These circumstances caused the damage to the beta cells of the pancreas either by the process of autoimmune or idiopathic so insulin production decreases even stalled. Hereditary factors (genetic) is suspected as the primary cause even though most children turned out to have no history on the DM family. Organs are pancreatic beta cells are the main work producing insulin. The result, the pancreas no longer able to meet the needs of the body's insulin production can even ceased altogether. As a comparison, normally the pancreas produces insulin unit 31 per day, whereas type 2 DM patients produce only 0-4 units per day; so it needs extra insulin from outside. Genetic and environmental factors will determine when and how severe the DM regarding the child.

Results (English) 2:

Type 1 diabetes is a systemic disorder resulting from interruption of glucose metabolism characterized by chronic hyperglycemia. The condition is caused by the destruction of pancreatic beta cells by both autoimmune and idiopathic process so that insulin production is reduced even halted. Heredity (genetics) is suspected as the main cause although most children did not have a family history of diabetes. Organs attacked are pancreatic beta cells that produce insulin main verb. As a result, the pancreas is no longer able to meet the needs of even the body's insulin production may be halted altogether. For comparison, normal pancreas to produce 31 units of insulin per day, whereas patients with type 1 diabetes produce only 0-4 units per day; and requires additional insulin from outside. Genetic and environmental factors will determine when and how severe the DM regarding children.